SIADH and hyponatraemia: foreword

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SIADH and hyponatraemia: foreword

Hyponatraemia is common, affecting about one in five of all hospitalized patients. Minor degrees of chronic hyponatraemia cause cognitive and motor impairment, and severe hyponatraemia is associated with substantial morbidity and mortality. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatraemia and is often poorly understood and inappropriately treat...

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SIADH and hyponatraemia: why does it matter?

The vasopressin-receptor antagonists have received approval for the treatment of hyponatraemia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). It is therefore necessary that physicians encountering hyponatraemia focus on SIADH. Recent studies show that hyponatraemia is often poorly managed-insufficient diagnostic tests are ordered and patients are undertreated...

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The diagnosis and management of inpatient hyponatraemia and SIADH

BACKGROUND Hyponatraemia is a very common medical condition that is associated with multiple poor clinical outcomes and is often managed suboptimally because of inadequate assessment and investigation. Previously published guidelines for its management are often complex and impractical to follow in a hospital environment, where patients may present to divergent specialists, as well as to genera...

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Hyponatraemia after Fracture Is Often Caused by Hypovolaemia, Not SIADH

We read with interest the study by Cervellin et al., the largest study of admission hyponatraemia in intracapsular femoral neck fractures to date [1]. This work adds to the substantial and growing body of evidence detailing associations between hyponatraemia and fractures. We agree that hyponatraemia is an important and underappreciated problem in femoral fractures and other fragility fractures...

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Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats.

BACKGROUND Although, pharmacological intervention with a selective arginine vasopressin (AVP) V(2) receptor antagonist has been demonstrated to be effective for syndrome of inappropriate secretion of antidiuretic hormone (SIADH), its long-term administration has some therapeutic limitations. Lithium, a drug for bipolar disorders, has been known to cause nephrogenic diabetes insipidus by reducin...

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ژورنال

عنوان ژورنال: Clinical Kidney Journal

سال: 2009

ISSN: 2048-8505,2048-8513

DOI: 10.1093/ndtplus/sfp152